Individuals (readers) who perform echocardiographic measurements blinded to patient randomization and CRT settings. PQ point (not the TP ) isoelectric line point of ST-segment measurement is 60 to 80 milliseconds after the J point. Patients blinded to which study group they randomized and how their CRT device is programmed. usual criterion 1 mm or greater or 0.1 mV or greater of horizontal or downsloping (i.e., <0.5 mV/sec) ST-segment depression in three consecutive beats. Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Informationġ:1 randomization - active comparator and experimental arm (note: at 6 months the control arm will crossover) Condition or diseaseĭevice: Reprogramming of CRT Device Settings to Optimal Electrical Synchrony This study looks to optimize new CRT device recipients using information obtained from standard ECG machines. Despite improvements in CRT technology with multipoint pacing, quadripolar leads, and adaptive pacing algorithms, approximately 30% of patients do not clinically benefit and are considered non-responders. Within the past decade, various multi-center randomized controlled trials have reported improved quality of life, aerobic exercise capacity, LV systolic function and structure, as well as decreased hospitalization rates and mortality among patients with HF.

A traditional CRT device has pacing leads implanted within the right atrium (RA), the right ventricle (RV), and within a coronary vein overlying the lateral or posterior left ventricle (LV). Why Should I Register and Submit Results?Ĭardiac resynchronization therapy (CRT), or atrial-synchronized biventricular (BiV) pacing, is an FDA-approved device therapy option for heart failure (HF) patients with reduced left ventricular ejection fraction and electrical dyssynchrony.

Ivcd ecg measurement